Autopsy report 15 minutes After class discussion of Part I, the instructor reports to the students that indeed all these cases do appear to be connected. Recall that the mitochondrion is sometimes called the “powerhouse” of the cell. It points out that the binding site of cyanide is an enzyme in the ETC. In order to determine which component of cellular respiration is affected, students must understand where these metabolites are used or produced and what their functions are. Toxicology reports show that the victims had been poisoned with cyanide. As Chief Medical Officer, you investigate suspicious deaths and provide toxicology services for the county. Most deaths were very rapid, occurring within a few hours of symptoms.
Students are asked to relate this information to their knowledge of the steps of cellular respiration to determine which stage has been affected. Role of cyanide You are now convinced that you know the cause of death for these victims and quickly report it back to the police as this is a very dangerous situation. Role of cyanide 20 minutes This last section of the case reveals that these patients have been poisoned with cyanide. Levels of pyruvate and acetyl coenzyme A CoA were normal. Brief scenarios surrounding the victims’ deaths and a list of symptoms they all had in common are given to the students.
In this section, students are asked to look for any abnormalities between the autopsy results and the cause of death. Students are often interested in the actual case of Tylenol poisoning, and the case can be ended with a discussion about the real-life Tylenol killer. While there were many suspects, no one was ever charged with the crime and it is still an ongoing investigation. The levels of key metabolites are reported in Table 1.
Role of cyanide 20 minutes This last section of the case reveals that these patients have been poisoned with cyanide. Inside the mitochondrion, there are several layers of membranes.
What is it called when a person “loves” another just based on their looks? This case is based vyanide on the real-life Chicago Tylenol murders in which seven people died from cyanide poisoning, which interrupts the function of the electron transport chain ETC.
Subcellular metabolite analysis 30 minutes Part III is the most in-depth section of the case study and requires more time for small-group and whole class discussion.
While there were many suspects, no one was ever charged case the respiration and it is cellular an ongoing investigation. What would you want to ask the families to answer these questions?
It is best to complete this case after information about cellular respiration has already been discussed in the course.
Part 2: Chicago Cyanide Murders- A Case Study in Cellular Respiration
Would artificial respiration or oxygenation have saved these people? Unfortunately, it’s been a busy week. It is your job to answer these questions before more deaths are reported. Investigators found that all of the victims had taken an extra strength tylenol hours before their death. What is causing these people to die? Subcellular metabolite analysis Detailed analysis of the damaged cells showed that ATP levels in the mitochondria were very low.
Part 2: Chicago Cyanide Murders- A Case Study in Cellular Respiration – Biology LibreTexts
After realizing that the electron transport chain was no longer functioning, you started to suspect poisoning and ran a blood test for various poisons that you knew affected the electron transport chain. Given what you know about cyanide poisoning, do you think that giving a person oxygen would be an effective treatment? Did God create Adam respiration, so at study one man would have the answer to speak cellular key interrupted? An expanded version of the teaching notes and the answer key may be found at the National Center for Case Study Teaching in Science at http: Are there any abnormalities in the levels of these metabolites in the victims?
You begin to suspect a malfunction of a specific cellular metabolic pathway and so you request a more ceellular analysis respiratiin the subcellular components of the affected cells from the autopsy. Looking back at the information you have about the people before they got sick, can you suggest a possible source of the cyanide poisoning?
What is an Adverb? Were the levels higher or lower than normal? Part II provides more detailed autopsy findings. In fact, these membranes resemble the membrane that surrounds the cell.
In the past 5 days, seven people have died, all with similar symptoms. The medical examiner concluded that each of the victims had died of hypoxia. Why is cyanide such an effective poison?
They gave her an extra strength Tylenol and sent her back to bed. The first was tsudy year-old girl.
During the whole respiiration discussion that follows, a list of questions is developed that the students believe should be asked as part of an epidemiological study. Why is the mitochondrion important? Her parents said that she was awake in the middle of the night complaining of a stuffy nose and sore throat.