SOLID SMEDDS THESIS

These results are in conformation with results reported in literature 19 — This article has been cited by other articles in PMC. Freshly prepared double distilled water was used. A small amount of oil in 0. Phase behavior and microstructure. Solubility Studies Equilibrium solubility of FK in various excipients and buffers was determined by shake flask method.

According to the plot increasing amount of Aerosil, increasing the MDT , is in accordance with the disintegration time of the pellets, while increasing crosscarmelose cause to decrease MDT. However, when a similar comparison was made for Pangraf capsules, statistically significant difference was not obtained on fifth day. In addition, it has an inhibitory effect on humoral immunity i. University of Mumbai, India, National Center for Biotechnology Information , U.

D thesis of Ms. The pellets were produced by the following processes: The formulation was characterized as transparent to milky dispersion.

Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus

Animals were divided into four groups of six animals each. As number and length of hydrophobic alkyl chains increases, molecular volume increases.

solid smedds thesis

FK SMEDDS formulation was superior to commercial formulation with respect to in vitro dissolution profile and in vivo immunosuppressant activity.

This increases molecular volume and affects penetration at interface. Furthermore, FK did not precipitated after dilution thesos a concentration of 1. Analytical methods used for calibration: The plot demonstrates that increasing the amount of crosscarmelose sokid to faster pellet disintegration.

  DISSERTATION RACINE ANDROMAQUE

Tacrolimus FKa member macrolide lactone isolated from Streptomyces tsukubaensi is a potent immunosuppressant and has been clinically used for preventing rejection of liver, heart, kidney, pancreas, lung and bone marrow after transplantation 1 — 3. This result could be related to the smaller droplet size of F Author information Article notes Copyright and License information Disclaimer.

In vitro dissolution profile of different pellets formulations are shown in Figure 3. To some extent, this combination offers the sum of the benefits of both SEDDS and solid dosage forms. Table 1 Independent variables factors and levels for factorial design. Bi-layered self-emulsifying pellets prepared by co-extrusion and spheronization: The size of microemulsion region was compared; larger the size, greater is the self-microemulsification efficiency.

The pellets were dried and characterized for size sieve analysisshape image analysismechanical strength friability testdroplet size laser light scattering and drug release rate dissolution test.

solid smedds thesis

However, when a similar comparison was made for Pangraf capsules, statistically significant difference was not obtained on fifth day. Go to Application Have a question? Among surfactants, Cremophore EL solubilize maximum amount of FK ; whereas zolid cosurfactants, Carbitol and propylene glycol exhibited good solubility for FK However it is reported that increasing the amount of SEDDS of the pellets tthesis granules would weaken the interaction within the pellets due to incomplete adsorption on pellets components and decrease their hardness.

  ANG EPEKTO NG BAWAL NA GAMOT ESSAY ALS

Preparation and evaluation of the self-emulsifying drug delivery system containing loratadine.

solid smedds thesis

Please review our privacy policy. The optimized formulation for in-In-vitro dissolution and pharmacodynamic studies was composed of Labrafac CM10 Author information Article notes Copyright and License information Disclaimer. All excipients and reagents were used as received. The effect of both Aerosil and crosscarmelose on disintegration time is shown as a surface plot Figure 2.

Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus

Establishment of new preparation method for solid dispersion formulation of tacrolimus. Oil and surfactant thewis accurately weighed in to glass vial. This may explained by emulsifying effect of solid components in the formulation.

Carbitol due to its superior solubilizing potential for FK was selected. Construction of Ternary Phase Diagram: No Batch Globule size Standard 1 A Abstract The objective of present investigation was to formulate self-microemulsifying drug delivery systems SMEDDS of tacrolimus FKa poorly water soluble immunosuppressant that exhibits low and erratic bioavailability.

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